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Having your own site to sell gently used handbags is probably going to be a really, really difficult endeavor for what its worth. It will be hard to get enough eyeballs/visitors on those bags to generate enough sales to make you any meaningful income (it’s an incredibly small niche and almost too specific in nature). Not to deter you from the idea completely but you’ll need to commit to several years of patience to really hit a home run in that field.
For instance, you might use Facebook’s Lookalike Audiences to get your message in front of an audience similar to your core demographic. Or, you could pay a social media influencer to share images of your products to her already well-established community. Paid social media can attract new customers to your brand or product, but you’ll want to conduct market research and A/B testing before investing too much in one social media channel.